Influence of levothyroxine treatment on serum levels of soluble Fas (CD95) and Fas Ligand (CD95L) in chronic autoimmune hypothyroidism
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چکیده
منابع مشابه
Aqueous Humor Levels of Soluble Fas and Fas-ligand in Patients with Primary Open Angle and Pseudoex-foliation Glaucoma
Background: Glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. In patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. Death of the trabecular meshwork cells may be a result of apoptosis. Objective: To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in ...
متن کاملCharacterization of Fas (Apo-1, CD95)-Fas ligand interaction.
The death-inducing receptor Fas is activated when cross-linked by the type II membrane protein Fas ligand (FasL). When human soluble FasL (sFasL, containing the extracellular portion) was expressed in human embryo kidney 293 cells, the three N-linked glycans of each FasL monomer were found to be essential for efficient secretion. Based on the structure of the closely related lymphotoxin alpha-t...
متن کاملaqueous humor levels of soluble fas and fas-ligand in patients with primary open angle and pseudoex-foliation glaucoma
background: glaucoma is one of the most common causes of blindness and is usually associated with elevated intraocular pressure. in patients with primary open angle glau-coma the number of trabecular meshwork cells is decreased. death of the trabecular meshwork cells may be a result of apoptosis. objective: to investigate the aqueous humor levels of soluble fas (sfas) and fas-ligand (sfasl) in ...
متن کاملCellular localization and function of Fas ligand (CD95L) in tumors.
The localization of CD95L in different cell types within tumors has not been well defined, and its role in tumor growth is uncertain. In this study, CD95L expression and its contribution to tumor growth are evaluated using genetic polymorphisms and adoptive transfer in genetically deficient mice. CD95L was detected in tumors in vivo at levels up to 10(4)-fold higher than those in cell culture a...
متن کاملStatus of FAS and FAS Ligand Gene Polymorphisms in Patients wi th Breast Cancer in Northeastern IRAN
Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...
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ژورنال
عنوان ژورنال: Endocrine
سال: 2010
ISSN: 1355-008X,1559-0100
DOI: 10.1007/s12020-010-9401-x